CX3CL1, a chemokine finely tuned to adhesion: critical roles of the stalk glycosylation and the membrane domain

The multi-domain CX3CL1 transmembrane chemokine triggers leukocyte adherence without rolling and migration by presenting its chemokine domain (CD) to its receptor CX3CR1.Through the combination of functional adhesion assays with structural analysis using FRAP, we investigated the functional role of the other domains of CX3CL1, i.e., its mucin stalk

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An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer

Abstract Background Anti-androgen resistance remains a major clinical challenge in the treatment of dorisvale station for sale prostate cancer (PCa), leading to disease progression and treatment failure.Despite extensive research on resistance mechanisms, a reliable prognostic model for predicting patient outcomes and guiding therapeutic strategies

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Range-Doppler domain spatial alignment for networked radars

Abstract An important prerequisite for the radar network detection is that the measurements from local radars are transformed to a common reference frame without systematic or registration errors.For the signal level alignment, only partial signals are available for global decision-making due to power and bandwidth limitations.In this paper, a low-

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What Drives Nighttime Tourism Intensity in Thailand? Evidence From Thai Attractions Based on Satellite Observations

Investigating nighttime tourism intensity in Thailand is crucial for the development of the local economy and related industries.Based on the satellite-observed nighttime light (NTL) data, points turbosound ts-18sw700/8a of interest data, and natural geographic condition data, this article explored the spatio-temporal distribution of the nighttime

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